Detalhe da pesquisa
1.
Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.
Cell
; 181(4): 832-847.e18, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32304665
2.
TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes.
Proc Natl Acad Sci U S A
; 120(38): e2218150120, 2023 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37695914
3.
Acetate mediates a microbiome-brain-ß-cell axis to promote metabolic syndrome.
Nature
; 534(7606): 213-7, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27279214
4.
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis.
Proc Natl Acad Sci U S A
; 116(49): 24770-24778, 2019 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31740614
5.
Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.
Proc Natl Acad Sci U S A
; 114(43): E9172-E9180, 2017 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073114
6.
Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.
Am J Physiol Endocrinol Metab
; 311(2): E461-70, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27406738
7.
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis.
Nat Commun
; 14(1): 8251, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38086791
8.
Loss of ZNF148 enhances insulin secretion in human pancreatic ß cells.
JCI Insight
; 8(11)2023 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37288664
9.
Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype.
bioRxiv
; 2023 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37398356
10.
UCP2-dependent redox sensing in POMC neurons regulates feeding.
Cell Rep
; 41(13): 111894, 2022 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36577374
11.
ß-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the KATP channel.
Elife
; 112022 08 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35997256
12.
Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.
J Clin Invest
; 132(3)2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34855620
13.
ß Cell-specific deletion of Zfp148 improves nutrient-stimulated ß cell Ca2+ responses.
JCI Insight
; 7(10)2022 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35603790
14.
Glucose Response by Stem Cell-Derived ß Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis.
Cell Rep
; 31(6): 107623, 2020 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32402282
15.
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health.
Cell Metab
; 32(5): 751-766.e11, 2020 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33147485
16.
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway.
Cell Metab
; 32(5): 736-750.e5, 2020 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33147484
17.
Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.
Nat Commun
; 10(1): 548, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30710078
18.
Mitochondrial GTP Links Nutrient Sensing to ß Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.
Cell Rep
; 28(3): 759-772.e10, 2019 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31315053
19.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Cell Rep
; 29(11): 3394-3404.e9, 2019 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31825824
20.
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.
Nat Genet
; 51(8): 1233-1243, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358993